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为了了解丙型肝炎病毒（HCV）不同功能区抗体的诊断价值，利用体外表达的HCVC、E1、E2／NS1、NS3、NS5蛋白作为重组抗原，按ELISA方法检测了已确诊为输血后丙型肝炎患者的血清112份。结果，检出率最高的是抗HCV—C（81．3％），最低的是抗HCV—E1（10．7％），输血后1个月内检出率最高的也是抗HCV—C（80％）。表明C蛋白是进行HCV诊断的最重要抗原。另外，动态观察10例输血后丙型肝炎患者抗体的变化，提示抗HCV—C，抗HCV—E2／Ns1，抗HCV—Ns3和抗HCV—Ns5抗体持续阳性可能是HCV在感染病人体内复制和丙型肝炎病程慢性化标志之一。
In order to understand the diagnostic value of antibodies in different functional areas of hepatitis C virus (HCV), the HCVC, E1, E2 / NS1, NS3 and NS5 proteins expressed in vitro were used as recombinant antigens to detect hepatitis C 112 patients serum. As a result, the highest detection rate was anti-HCV-C (81.3%), the lowest was anti-HCV-E1 (10.7%), and the highest detection rate within 1 month after transfusion was also anti-HCV-C 80%). The protein C is the most important antigen for HCV diagnosis. In addition, the dynamic observation of 10 patients with hepatitis C after transfusion changes in antibodies, suggesting that anti-HCV-C, anti-HCV-E2 / Ns1, anti-HCV-Ns3 and anti-HCV-Ns5 antibodies may be sustained HCV infection in patients with in vivo replication and Hepatitis C disease one of the signs of chronicity.