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目的:比较常规外放疗与合并组织间近距离照射对脑生殖细胞瘤的疗效和预后.方法:自1993年4月～1997年12月,脑脑生殖细胞瘤共23例,其中13例(手术后11例,无病理者2例)单用外放疗,剂量为全脑30Gy/4周,局部剂量20～25Gy/2～3周;10例病人行立体定向置管后装近距离治疗合并外放疗,近距离治疗剂量为20～25Gy/8～10次/7～10天,之后行全脑外放疗30Gy/4周;对其中有脑室侵犯者给予全脊髓放疗25～30Gy/3～4周.结果:放疗结束后3个月行CT或MRI检查示病灶基本消失.3年生存率分别为单用外放疗组87.5%(7/8),合并近距离治疗组100%(6/6).随诊期内所有病例未出现严重并发症.结论:(1)近距离治疗配合外放疗的疗效与单纯外放疗相比无明显差异.(2)所有病例未出现严重放射性并发症.
OBJECTIVE: To compare the efficacy and prognosis of brain germ cell tumor with conventional external beam radiotherapy and brachytherapy with combined tissue.Methods: From April 1993 to December 1997, a total of 23 cases of brain germ cell tumor, including 13 cases After 11 cases, no pathology in 2 cases) single external radiotherapy, the dose of the whole brain 30Gy / 4 weeks, the local dose of 20 ~ 25Gy / 2 ~ 3 weeks; 10 patients underwent stereotactic catheterization after brachytherapy combined Radiotherapy, brachytherapy dose of 20 ~ 25Gy / 8 ~ 10 times / 7 ~ 10 days, followed by whole-brain radiotherapy 30Gy / 4 weeks; of which have ventricular invasion were given whole spinal cord radiotherapy 25 ~ 30Gy / 3 ~ 4 weeks Results: Three months after the end of radiotherapy, CT or MRI showed that the lesions basically disappeared.The 3-year survival rates were 87.5% (7/8) in the single external-radiotherapy group and 100% (6/6) in the brachytherapy group, respectively No serious complications occurred in all the cases during the follow-up.Conclusion: (1) There is no significant difference between brachytherapy and external beam radiotherapy (2) No serious radioactive complications occurred in all cases.