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目的:分析Grave′s病患者131碘治疗后的血清TRAb变化,探讨TRAb在131碘治疗甲亢中的应用价值。方法:采用放射受体分析法检测了101例131碘治疗的Grave′s病患者血清TRAb,根据131碘治疗后对血清TRAb变化进行对比分析。结果:甲亢持续组TRAb升高阳性率明显高于甲亢治愈组,两者之间差异有显著性(P<0.05)。而在131碘治疗后TRAb的变化与甲亢严重无关(P>0.05)。结论:TRAb检测在Grav′s病131碘治疗中具有重要指导作用。
OBJECTIVE: To analyze the change of serum TRAb level after 131I treatment in Grave’s disease patients and to explore the value of TRAb in 131I treatment of hyperthyroidism. Methods: Radioimmunoassay was used to detect serum TRAb in 101 patients with 131I-treated Grave’s disease. The changes of serum TRAb after 131I-iodine treatment were compared. Results: The positive rate of TRAb in the persistent hyperthyroidism group was significantly higher than that in the hyperthyroidism-cured group, the difference was significant (P <0.05). The change of TRAb after 131I treatment was not related to the severity of hyperthyroidism (P> 0.05). CONCLUSIONS: TRAb testing plays an important guiding role in the treatment of 131I in Grav’s disease.