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已有人报告特应性患者发生特发性肾病综合征(INS)。该病在初发复发前常有呼吸道症状,有时发生预防接种之后。INS 患者可有血 IgE 水平高,该值和变态反应患者的浓度相似,但 INS 和 IgE 嗜碱粒细胞系统问的关系尚未完全肯定。作者用变应原特异性人嘈碱粒细胞脱颗粒试验(HBDT)作为 IgE-依赖细胞应答指标,研究了 INS 患者的变态反应状态。有或无特应性表现的 INS 患者46例,其中微小病变型肾病综合征(MCNS)28例(平均36岁),灶性节段性肾小球硬化症(FSGS)18例(平均38岁)。另外用29例各种类型肾小球肾炎(GN)患者(膜性GN10例,IgA 系膜性 GN11例,膜增殖性 GN 8例)和健康人11例,作为对照组。结果发现16/28例(57%)
It has been reported in atopic patients with idiopathic nephrotic syndrome (INS). The disease is often preceded by recurrent respiratory symptoms, sometimes after vaccination. The level of serum IgE in patients with INS is high, which is similar to the concentration in patients with allergies, but the relationship between INS and IgE basophils is not fully understood. The authors used the allergen-specific human noisy alkaline granulocyte degranulation test (HBDT) as an IgE-dependent cellular response to investigate the allergic state in patients with INS. There were 46 INS patients with or without atypia, including 28 patients with minimal change nephrotic syndrome (MCNS) (average 36 years) and 18 patients with focal segmental glomerulosclerosis (FSGS) ). In addition, 29 cases of various types of glomerulonephritis (GN), including 10 cases of membranous GN, 11 cases of IgA mesangial GN, 8 cases of proliferative GN, and 11 healthy subjects were selected as the control group. As a result, 16/28 patients (57%)