目的探讨动脉血管内灌注维拉帕米治疗神经介入手术中脑血管痉挛的有效性及安全性。方法脑动脉瘤介入术中出现的影像学脑血管痉挛15例,均经导管向动脉血管内灌注维拉帕米治疗。比较灌注前、后脑血管直径的变化,并记录灌注治疗过程中患者的心率和平均动脉压。结果本组15例共实施了15根脑动脉血管内的灌注治疗,11例痉挛血管获得影像学改善。灌注前、后心率和平均动脉压均无明显改变[(78±11)次/分vs.(79±12)次/分和(108±13)mm Hg vs.(110±14)mm Hg](P>0.05)。结论动脉血管内灌注维拉帕米治疗脑动脉瘤介入术中的脑血管痉挛安全、有效。 Objective To investigate the effectiveness and safety of intra-arterial infusion of verapamil in the treatment of cerebral vasospasm during nerve interventional surgery. Methods Fifteen cases of cerebral vasospasm occurred during the interventional treatment of cerebral aneurysm. All of them were treated by intra-arterial infusion of verapamil through the catheter. The changes of vessel diameter before and after perfusion were compared, and the heart rate and mean arterial pressure of patients during perfusion therapy were recorded. Results The group of 15 patients implemented a total of 15 cerebral artery perfusion therapy, 11 cases of spasm vascular imaging improved. There were no significant changes in heart rate and mean arterial pressure before and after perfusion (78 ± 11 vs. 79 ± 12 and 108 ± 13 mm Hg vs. 110 ± 14 mm Hg) (P> 0.05). Conclusion Intra-arterial infusion of verapamil is safe and effective in the treatment of cerebral vasospasm during cerebral aneurysm intervention.