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胃癌是最常见的消化道恶性肿瘤,其腹膜种植转移是影 响预后的重要因素,本实验通过对胃癌高侵袭转移细胞株表 面hB7 1,MHCⅠ、Ⅱ的表达以及hB7 1基因转染对其生长特 性和免疫原性影响的研究,为进一步开展基因治疗提供免疫 学依据。 1 材料与方法 1.1 病毒及细胞 腺病毒载
Gastric cancer is the most common malignant tumor of the digestive tract. The peritoneal metastasis is an important factor that influences the prognosis. In this experiment, the expression of hB7 1, MHC I, II on the surface of high invasion and metastasis cell lines of gastric cancer and the growth characteristics of hB7 1 gene were studied in this experiment. The study of the effects of immunogenicity provides immunological basis for the further development of gene therapy. 1 Materials and Methods 1.1 Viruses and Cells Adenovirus Loading