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本文将胎垂体细胞分别放入含与不含1.0μg/ml环孢素A(CsA)的两种培养液中培养2周,经免疫电镜检查及培养的细胞免疫家兔测定兔血清中抗人胎脑抗体效价的方法,证实在含CsA培养液中培养的细胞的免疫原性,较同期在不含CsA培养液中培养的细胞的免疫原性明显降低。结果提示:用CsA预处理胎垂体细胞,可显著降低其免疫原性。
In this study, fetal pituitary cells were cultured in two different culture mediums containing and without cyclosporine A (CsA) at 1.0μg / ml for 2 weeks respectively. Rabbit serum anti-human The fetal antibody titer assay demonstrated that the immunogenicity of cells cultured in CsA-containing broth was significantly lower than that of cells cultured in CsA-free broth over the same period. The results suggest that pretreatment of fetal pituitary cells with CsA can significantly reduce its immunogenicity.