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观察健康人外周血淋巴细胞在体外对抗 CD_3单克隆抗体(CD_3McAb)+IL-2联合刺激的反应性。结果发现 CD_3McAb 能单独激活健康人外周血淋巴细胞,激活浓度范围广泛。IL-2与CD_3McAb 联合应用有明显协同作用。经 CD_3McAb+IL-2刺激后,细胞类型主要是 CD_8~+细胞。激活后的淋巴细胞 IL-2R 表达明显升高。
Observe the reactivity of peripheral blood lymphocytes in healthy individuals against the combined stimulation of CD_3 monoclonal antibody (CD_3McAb) + IL-2 in vitro. It was found that CD_3McAb can activate peripheral blood lymphocytes in healthy individuals, with a wide range of activation concentrations. There is a clear synergy between the combination of IL-2 and CD_3McAb. After stimulation with CD_3McAb+IL-2, the cell type was mainly CD_8~+ cells. IL-2R expression was significantly increased in activated lymphocytes.