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目的:探讨原发性胆囊癌(PGC)组织中癌症高表达蛋白(Hec 1)的表达与浸润、转移及预后的关系。方法:首先,随机选取PGC患者108例,以慢性胆囊炎患者15例为对照,应用SABC免疫组化方法检测Hec 1蛋白的表达。其次,对108例PGC患者中的96例进行术后5年的随访,分析Hec 1与PGC患者预后的关联。结果:Hec 1蛋白的表达与PGC组织的临床病理学特征及患者的预后均有密切的关系。在发生淋巴道转移及低分化的肿瘤组织中,Hec 1蛋白高表达。随着Nevin分级的加重,Hec 1蛋白的阳性表达率明显增加(P<0.05)。此外,Hec 1蛋白阳性表达的PGC患者的5年生存率明显低于阴性表达的患者(P<0.01)。结论:Hec 1蛋白可能与PGC的发生、浸润、转移有关;联合应用Hec 1蛋白阳性表达率与其临床病理学分级,有助于正确判断患者的预后。
Objective: To investigate the relationship between the expression of Hec 1 protein and invasion, metastasis and prognosis in primary gallbladder carcinoma (PGC). Methods: First, we randomly selected 108 patients with PGC and 15 patients with chronic cholecystitis as control. The expression of Hec 1 protein was detected by SABC immunohistochemistry. Second, 96 out of 108 PGC patients were followed up for 5 years. The correlation between Hec 1 and PGC prognosis was analyzed. Results: The expression of Hec 1 protein was closely related to the clinicopathological features and prognosis of PGC. Hec 1 protein is overexpressed in lymphatic metastasis and poorly differentiated tumor tissues. With the increase of Nevin grade, the positive expression rate of Hec 1 protein increased significantly (P <0.05). In addition, the 5-year survival rate of HeC-1 positive PGC patients was significantly lower than that of negative patients (P <0.01). Conclusion: The Hec 1 protein may be related to the occurrence, invasion and metastasis of PGC. The combined application of Hec 1 protein and its clinicopathological grade may help to judge the prognosis of patients.