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单细胞微生物在铁的浓度小于10~(-6)mol·dm~(-3)时分泌Siderophores,此物质在近中性的条件下摄取外界的铁。其中一类为他Catechloate Siderophores(例如enterobactin)。enterobactin 有很强的配合Fe(Ⅲ)的能力。但铁如何从 Fe(Ⅲ)的enterobactin的配合物中释放出来,目前尚不清楚。Fe(Ⅲ)的2,3-二羟基苯甲酸体系提供了研究该机理的模式。镰形细胞性贫血和重型库利氏贫血(β-thalasemia)的输血治疗引起铁在肝、胰和心脏中的不断积累,导致这些器官纤维损伤和功能丧失。虽然2,3-二羟基苯甲酸是治疗此类贫血病的制剂,但对Fe(Ⅲ)的2,3-二羟基苯甲酸体系的热力学性质还没有深入研究,其动力学和机理的研究亦未见报道。
Single-celled microorganisms secrete Siderophores at iron concentrations less than 10 -6 mol · dm -3, which ingest iron from the outside under near-neutral conditions. One of them is Catechloate Siderophores (eg enterobactin). Enterobactin has a strong ability to match Fe (Ⅲ). However, it is unclear how iron is released from the enterobactin complex of Fe (III). The 2,3-dihydroxybenzoic acid system of Fe (III) provides a model for studying this mechanism. Blood transfusions of sickle cell anemia and severe thalassemia cause an accumulation of iron in the liver, pancreas and heart, resulting in fiber damage and loss of function in these organs. Although 2,3-dihydroxybenzoic acid is a preparation for the treatment of such anemias, the thermodynamic properties of the 2,3-dihydroxybenzoic acid system of Fe (III) have not been further investigated, and the kinetics and mechanism of this No reports.