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分析急性间质肾炎 (AIN)肾间质中浸润的淋巴细胞亚型的意义。方法19例AIN患者根据肾活检前的血清肌酐值 (SCr)分为SCr >5 0 0 μmol/L组 (A组 )及SCr <5 0 0 μmol/L(B组 ) ;根据病人入院 30d时的血清肌酐分为SCr恢复正常组 (Ⅰ组 )及SCr未恢复正常组 (Ⅱ组 )。所有病人行肾穿刺活检 ,肾间质淋巴细胞亚型的检测采用SABC法。结果病理改变均表现为不同程度的间质炎性细胞浸润 ,以淋巴细胞为主 ,淋巴细胞亚型以CD+4 和CD+8细胞居多 ,CD+2 0 细胞较少 ;A组肾间质中的淋巴细胞明显多于B组 (P<0 .0 5 ) ;Ⅱ组间质中CD+4 及CD+8细胞明显多于Ⅰ组 (P <0 .0 1)。结论间质浸润淋巴细胞越多 ,肾功能越差 ,AIN的预后也越差 ;细胞免疫在AIN发病机制中起着重要作用。
To analyze the significance of infiltrating lymphocyte subtype in interstitial of acute interstitial nephritis (AIN). Methods 19 cases of AIN patients were divided into SCr> 500 μmol / L group (SC) and SCr <500 μmol / L group B according to serum creatinine before renal biopsy. According to the patients admitted to hospital Serum creatinine at 30 days was divided into normal SCr group (group Ⅰ) and normal SCr group (group Ⅱ). All patients underwent renal biopsy, renal interstitial lymphocyte subtypes detected by SABC method. Results pathological changes showed varying degrees of interstitial inflammatory cell infiltration, mainly lymphocytes, lymphocyte subtype of CD + 4 and CD + 8 cells are mostly CD + 20 cells less; A group of kidney Interstitial lymphocytes were significantly more than those in group B (P <0.05). The number of CD + 4 and CD + 8 cells in group II was significantly higher than that in group I (P <0.01). Conclusions 越 The more interstitial infiltrating lymphocytes, the worse the renal function, the worse the prognosis of AIN. Cellular immunity plays an important role in the pathogenesis of AIN.