目的探讨枯草芽孢杆菌活菌制剂对创伤皮肤愈合的影响。方法以大鼠后背全层皮肤切除创伤愈合过程为模型,局部外用枯草芽孢杆菌活茵制剂并设对照,制作病理组织切片,测定创面羟脯氨酸含量变化,同时测量创面愈合面积,记录愈合时间。结果应用枯草牙孢杆菌活菌制剂可促进成纤维细胞增生,提高胶原含量,创面愈合时间较对照组明显缩短。结论枯草牙孢杆茵活茵制剂具有促进创伤皮肤愈合的作用。 Objective To investigate the effect of Bacillus subtilis on skin wound healing. Methods The wound healing process of the full thickness of the skin of the back of the rats was taken as the model. The local topical Bacillus subtilis injection was used as a control. The histopathological sections were made and the content of hydroxyproline in wounds was measured. The wound healing area was also measured. time. Results Bacillus subtilis viable preparations can promote fibroblast proliferation, increase collagen content, wound healing time was significantly shorter than the control group. Conclusion Bacillus subtilis Yin Yin Yin preparations have the role of promoting wound healing.