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目的探讨重组人脑利钠肽(rh BNP)治疗急性心肌梗死泵衰竭对患者基础体征及心功能的影响。方法选择舞钢职工医院2013年11月至2014年11月收治的64例急性心肌梗死泵衰竭患者,按随机数字表法分为对照组与观察组,每组32例。对照组接受常规治疗;观察组同时给予rh BNP。统计治疗前后心率、血氧饱和度(Sa O2)等体征指标,检测左心室收缩末期容量(LESV)、左心室舒张末期容量(LEDV)及左室射血分数(LVEF),观察两组治疗效果。结果治疗后,观察组心率、Sa O2等基础体征指标[(88.64±9.13)次/min、(98.56±6.23)%]及LESV、LVEDV、LVEF等心功能指标[(103.15±52.38)ml、(58.37±43.62)ml、(52.37±9.58)%]改善情况均优于对照组(P<0.05);较对照组,观察组治疗总有效率(87.5%)高,两组比较差异有统计学意义(P<0.05)。结论 rh BNP治疗急性心肌梗死泵衰竭有利于促进患者基础体征尽快恢复,改善心功能,疗效确切,适合于临床推广。
Objective To investigate the effect of recombinant human brain natriuretic peptide (rh BNP) on patients with underlying heart failure and heart failure during pump failure of acute myocardial infarction. Methods Sixty-four patients with acute myocardial infarction with pump failure treated in Wugang Workers’ Hospital from November 2013 to November 2014 were divided into control group and observation group according to random number table method, with 32 cases in each group. Control group received routine treatment; observation group also given rh BNP. The heart rate, blood oxygen saturation (Sa O2) and other signs were measured before and after treatment. The left ventricular end-systolic volume (LESV), left ventricular end-diastolic volume (LVEF) and left ventricular ejection fraction (LVEF) . Results After treatment, heart function indexes such as heart rate and Sa O2 [(88.64 ± 9.13) / min, (98.56 ± 6.23)%] and heart function index [(103.15 ± 52.38) ml, LESV, LVEDV and LVEF, 58.37 ± 43.62) ml, (52.37 ± 9.58)%] were better than the control group (P <0.05). Compared with the control group, the total effective rate of the observation group was 87.5%, the difference was statistically significant (P <0.05). Conclusion rh BNP treatment of acute myocardial infarction pump failure is conducive to promoting the recovery of patients with basic signs as soon as possible to improve cardiac function, curative effect is exact, suitable for clinical promotion.