目的　为深入了解新生儿早期肾功、体液状态并寻找其检测方法以保护发育不完善的肾功能和维持体液平衡 ,对 12 2例新生儿早期 (0— 5天 )的血、尿溶质各成份尿渗透压、尿钠等进行测定并计算肾功指数 :内生肌酐清除率、钠排泄分数、渗透性溶质清除率、纯水清除率 ,结果表明早产、早产窒息儿尿溶质排泄明显高于足月儿 (对照组 ) ,窒息儿尿渗透压明显高于非窒息儿 ,且有显著差异 (P <0 .0 1)。早产窒息组溶质排泄分数、渗透性溶质清除率及纯水清除率均高于对照组。窒息组肾溶质负荷达正常范围值高限 ,故认为上述检测指标与早产儿肾发育成熟程度、窒息肾功受损程度密切相关 OBJECTIVE To understand the status of early renal function and fluid in newborns and to find out its detection method to protect underdeveloped renal function and maintain body fluid balance, the purpose of this study was to investigate the effect of blood and urine solutes on early neonates (0-5 days) Urine osmotic pressure, urinary sodium were measured and calculated renal index: endogenous creatinine clearance, sodium excretion fraction, osmotic solute clearance rate, pure water clearance rate, the results show that premature children with preterm asphyxia urinary excretion was significantly higher than the foot Month (control group), asphyxia urinary osmotic pressure was significantly higher than non-asphyxia children, and there was a significant difference (P <0.01). Preterm asphyxia group solute excretion fraction, permeability solute clearance rate and pure water clearance rate were higher than the control group. Asphyxia group renal solute load up to the normal range of high value, so that the above indicators and premature children with renal maturity, renal injury is closely related to the degree of asphyxia