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应用猪肝细胞生长因子(HOF)治疗CCl_4诱发的小鼠急性肝损伤及D-半乳糖胺诱发的大鼠暴发性肝衰竭(FHF)。结果表明,HGF可迅速降低急性肝损伤小鼠转氨酶(ALT)水平,与联苯双酯相似。修复肝损伤优于联苯双酯。治疗HFH大鼠,30天存活率47.8％,盐水组仅为17.3％(P<0.05)。HGF的疗效除与促进肝细胞再生外,尚可能与激发机体的免疫状态及与制剂中含有的核酸及Zn、Se等微量元素有关。
The application of porcine hepatocyte growth factor (HOF) in the treatment of CCl_4 induced acute liver injury in mice and D-galactosamine induced fulminant hepatic failure (FHF) in rats. The results showed that HGF can rapidly reduce transaminase (ALT) levels in mice with acute liver injury, similar to that of bifendate. Repairing liver damage is superior to biphenyl diester. In the HFH rats, the survival rate was 47.8% at 30 days and only 17.3% in the saline group (P<0.05). In addition to promoting the regeneration of hepatocytes, the efficacy of HGF may be related to the stimulation of the body’s immune status and the nucleic acids contained in the preparations and trace elements such as Zn and Se.