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目的探讨布地奈德吸入治疗小儿毛细支气管炎的临床疗效。方法选取万年县人民医院2013年3月—2016年3月收治的毛细支气管炎患儿80例,根据治疗方法不同分为对照组与研究组,各40例。对照组予以常规治疗,研究组在对照组基础上加用布地奈德治疗,两组患儿均持续治疗5~7 d,比较两组患儿临床疗效、临床指标(止咳时间、平喘时间、住院时间、肺部哮鸣音和湿啰音消失时间、气道阻力)及不良反应发生情况。结果研究组患儿临床疗效优于对照组(P<0.05)。研究组患儿止咳时间、平喘时间、住院时间、肺部哮鸣音消失时间和湿啰音消失时间短于对照组,气道阻力低于对照组(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论布地奈德吸入治疗小儿毛细支气管炎的临床疗效确切,可有效改善患儿临床症状,缩短治疗时间,恢复患儿异常状态,且安全性高。
Objective To investigate the clinical efficacy of budesonide inhalation in children with bronchiolitis. Methods Eighty children with bronchiolitis who were treated in Wannian County People’s Hospital from March 2013 to March 2016 were selected and divided into control group and study group with 40 cases in each group. The control group was given conventional treatment. The study group was treated with budesonide on the basis of the control group. The children in both groups were treated continuously for 5 to 7 days. The clinical curative effect, clinical indexes (cough time, antiasthmatic time, Length of hospital stay, wheeze and wet rales disappeared, airway resistance) and adverse events. Results The clinical efficacy of study group was better than that of control group (P <0.05). The cough time, asthma relief time, length of hospital stay, disappearance time of lung wheeze and disappearance of wet rales were shorter in the study group than in the control group, and the airway resistance was lower in the study group than in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The clinical efficacy of budesonide inhalation in the treatment of children with bronchiolitis is exact, which can effectively improve the clinical symptoms, shorten the treatment time and restore the abnormal state of children with high safety.