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目的:分析研究重型颅脑损伤合并脑耗盐综合征患者的临床表现以及血浆利钠肽浓度改变情况,为临床提供有力的依据。方法:选取我院在2015年1月到2016年1月所收治的重型颅脑损伤合并脑耗盐综合征患者资料50例开展回顾性分析,将其作为研究组,同期选取单纯重型颅脑损伤患者资料50例作为非脑耗盐综合征组,选取健康体检人群50例作为对照组,统计三组患者在入院当天、入院第五天、入院第十天以及入院第十五天的血浆利钠肽以及血钠浓度,同时给予患者经颅多普勒超声检查,对患者的大脑中动脉以及大脑前动脉血流速度进行检测。结果:研究组患者在入院第五天的血浆利钠肽水平升高,与其它两组对比存在统计学意义(P<0.05);研究组患者经颅多普勒超声检查结果表明脑血流速度显著提升,与其他两组比较存在统计学意义(P<0.05);持续大概在10天左右,2周之后脑血流速度恢复到正常值,和血钠水平波动一致。结论:重型颅脑损伤合并脑耗盐综合征患者的血浆利钠肽浓度显著提升,表明血浆利钠肽水平和脑耗盐综合征的出现密切相关,临床中需要给予重视。
OBJECTIVE: To analyze the clinical manifestations of patients with severe traumatic brain injury and brain damage salt syndrome and the changes of plasma natriuretic peptide concentration, so as to provide a strong basis for clinical practice. Methods: A retrospective analysis of 50 patients with severe craniocerebral injury complicated with traumatic salt syndrome admitted in our hospital from January 2015 to January 2016 was retrospectively analyzed. The patients were selected as the study group, while patients with severe craniocerebral injury Fifty cases of patients with non-cerebrovascular salt syndrome were selected as the control group. Fifty healthy people were selected as the control group. The three groups of patients on the day of admission, the fifth day of admission, the tenth day of admission and the fifteenth day of admission, Peptide and serum sodium concentration, while patients given transcranial Doppler ultrasound examination of the patient’s middle cerebral artery and anterior cerebral artery blood flow velocity was detected. Results: The level of plasma natriuretic peptide increased in the study group on the fifth day after admission, which was statistically significant compared with the other two groups (P <0.05). The transcranial Doppler echocardiography in the study group showed that the cerebral blood flow velocity (P <0.05). After about 10 days, the cerebral blood flow velocity returned to normal after two weeks and was consistent with the fluctuation of serum sodium level. CONCLUSIONS: The concentration of plasma natriuretic peptide in patients with severe craniocerebral injury complicated with cerebrospinal fluid syndrome is significantly increased, indicating that plasma natriuretic peptide level is closely related to the occurrence of salt-depleted brain syndrome and needs to be paid more attention in clinic.