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目的:探讨丹红注射液对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)后再灌注损伤的保护作用及可能机制。方法:随机将AMI患者分为丹红注射液组(n=30)和对照组(n=30),丹红注射液组给予PCI+常规药物+丹红注射液治疗,对照组给予PCI+常规药物治疗。检测PCI后6h、PCI后12h、PCI后24h血中CK-MB值并分析其峰值。在PCI术后6个月采用超声心动图利用IBS技术检测受累心肌的IBS%,IBS周期变化幅度(cycle variation of IBS,CVIB),N-延迟相比较。结果:丹红组出现的再灌注心律失常明显低于生理盐水组,有显著差异(P<0.01);PCI术前两组的CK-MB值没有明显差异,而术后观察到丹红组CK-MB明显低于生理盐水对照组(P<0.01);与丹红组梗死区比较,生理盐水组梗死区心肌心肌IBS增大,CVIB减低均有统计学意义(P<0.01)。结论:丹红注射液具有抑制PCI后炎症、抗心肌缺血-再灌注损伤、抑制心肌重塑的作用。
Objective: To investigate the protective effect and possible mechanism of Danhong injection on reperfusion injury after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Methods: Patients with AMI were randomly divided into Danhong injection group (n = 30) and control group (n = 30). Danhong injection group was given PCI plus conventional drug plus Danhong injection. The control group was given PCI plus conventional drug treatment . CK-MB was measured at 6h after PCI, 12h after PCI and 24h after PCI, and the peak value was analyzed. Echocardiography was performed at 6 months after PCI to compare IBS% of affected myocardium with IBS (CVBIB) and N-delay in IBS using IBS technique. Results: The reperfusion arrhythmia in Danhong group was significantly lower than that in normal saline group (P <0.01). There was no significant difference in CK-MB between the two groups before operation -MB was significantly lower than that of the saline control group (P <0.01). Compared with the infarction area of Danhong group, IBS increased and CVIB decreased significantly (P <0.01) in the myocardial infarction group. Conclusion: Danhong injection can inhibit inflammation, anti-myocardial ischemia-reperfusion injury and inhibit myocardial remodeling after PCI.