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人体的许多组织器官都由相应的特应性干细胞发育而来。研究发现,记忆性淋巴细胞群中也存在一小部分具有干细胞特性的细胞,命名为T记忆干细胞(TSCM)。这类细胞占外周总循环T淋巴细胞的2%~4%,可以分化为中枢记忆T细胞(TCM)、效应记忆T细胞(TEM)和终末分化效应T细胞,并且可以利用自我更新复制能力来维持一定的数量。近期研究发现,T记忆干细胞在人类艾滋病病毒(HIV)感染的发病机制中发挥着关键作用,在其内潜伏的HIV-1是病毒潜伏库的重要组成部分。文章将总结TSCM细胞在HIV感染中的一些新发现,探讨其与潜伏库的关系。
Many of the body’s tissues and organs are developed from the corresponding atopic stem cells. The study also found that a small number of cells with stem cell characteristics also exist in the memory lymphocyte population and are named T memory stem cells (TSCM). Such cells account for 2% to 4% of the total circulating peripheral T lymphocytes and can differentiate into central memory T cells (TCMs), effector memory T cells (TEMs), and terminally differentiated effector T cells and can utilize self-renewal replication capacity To maintain a certain amount. Recent studies have found that T memory stem cells play a key role in the pathogenesis of human immunodeficiency virus (HIV) infection, in which latent HIV-1 is an important part of the viral latent library. The article will summarize some new findings of TSCM cells in HIV infection and explore their relationship with latent libraries.