结核性脑膜炎 (ＴＢＭ )是肺外结核常见临床表现之一。2 0 %死于活动性结核的患儿在尸检时呈现有脑膜炎或中枢神经系统受损 ,常规细菌学检测方法不仅耗时且灵敏度差。作者报道用点免疫结合法 (Ｄｏｔ Ｉｂａ)检测ＣＳＦ中结核杆菌抗原。ＣＳＦ标本采自 40例临床诊断为ＴＢＭ的 Tuberculous meningitis (TBM) is one of the common clinical manifestations of extrapulmonary tuberculosis. 20% of children with active TB died of meningitis or CNS damage at autopsy, and routine bacteriological tests are not only time-consuming and have poor sensitivity. The authors report the detection of Mycobacterium tuberculosis antigens in CSF by dot immunobinding (Dot Iba). CSF samples were collected from 40 clinically diagnosed TBM