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目的:对老年慢性阻塞性肺疾病(COPD)呼吸衰竭患者全血胆碱酯酶(CHE)的表达及临床意义进行分析探讨。方法:将我院2013年1月~2016年12月收治的60例老年COPD合并呼吸衰竭患者作为观察组,以同期收治的60例老年COPD未合并呼吸衰竭患者做为对照组,对比两组患者治疗前后的全血CHE水平。结果:观察组患者治疗前全血CHE为(34.31±5.28)U/L,明显低于对照组的(7320.91±944.25)U/L(P<0.05)。观察组治疗后全血CHE水平为(6231.88±873.53)U/L,与治疗前相比具有统计学意义(P<0.05)。结论:CHE能够作为老年COPD呼吸衰竭患者病情与预后评价的重要指标,应引起临床重视。
Objective: To investigate the expression and clinical significance of whole blood cholinesterase (CHE) in elderly patients with chronic obstructive pulmonary disease (COPD) respiratory failure. Methods: Sixty elderly COPD patients with respiratory failure admitted to our hospital from January 2013 to December 2016 were selected as the observation group. Sixty elderly COPD patients without respiratory failure were enrolled as the control group. The patients in the two groups were compared Whole blood CHE levels before and after treatment. Results: Before treatment, CHE in whole blood of the observation group was (34.31 ± 5.28) U / L, which was significantly lower than that of the control group (7320.91 ± 944.25) U / L (P <0.05). The level of CHE in whole blood after treatment in the observation group was (6231.88 ± 873.53) U / L, which was significantly higher than that before treatment (P <0.05). Conclusions: CHE can be used as an important index to evaluate the condition and prognosis of elderly COPD patients with respiratory failure, and should be clinically valued.