论文部分内容阅读
一、变态反应性疾病:激素对支气管哮喘(下称哮喘)、嗜酸性细胞增多性肺浸润、外源性过敏性肺泡炎等有肯定疗效,尤以哮喘疗效最好。哮喘的主要发病机制为:①有过敏性体质的病人,在过敏原刺激下发生Ⅰ型变态反应,导致支气管粘膜水肿、渗出及痉挛;②迷走神经及交感神经兴奋性不平衡;③β受体的敏感性降低,致支气管平滑肌细胞内cAMP水平或cAMP/cGMP比值下降(cAMP水平直接影响支气管平滑肌的舒缩及炎症介质的释放)。而糖皮质激素可通过稳定溶酶体膜,减
First, the allergic diseases: hormones on bronchial asthma (hereinafter referred to as asthma), eosinophilic pulmonary infiltrates, exogenous allergic alveolitis and so have a positive effect, especially in the best efficacy of asthma. The main pathogenesis of asthma: ① patients with allergic constitution, allergen-induced type Ⅰ allergic reaction, leading to bronchial mucosal edema, exudation and spasm; ② vagus nerve and sympathetic excitability imbalance; ③ β receptor Sensitivity decreased, resulting in bronchial smooth muscle cells cAMP levels or cAMP / cGMP ratio decreased (cAMP level directly affects the bronchial smooth muscle contraction and release of inflammatory mediators). Glucocorticoids can be stabilized by lysosomal membrane, minus