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目的比较中晚期子宫颈癌采用单药顺铂、多西紫杉醇联合顺铂同步放化疗与单纯放疗的疗效与毒性反应。方法回顾性分析98例ⅡB~ⅢA期子宫颈癌患者的临床病理资料。根据治疗方法分为A组(放疗联合顺铂同步放化疗组)、B组:(放疗联合多西紫杉醇加顺铂同步放化疗组)和C组(单纯放疗组)。观察三组的疗效与毒性反应。结果 A、B、C组治疗有效率分别为86.5%(32/37)、90.2%(37/41)、65.0%(13/20),三组比较,差异有统计学意义(P=0.037)。A、B、C组发生Ⅲ~Ⅳ度白细胞降低比例分别为51.4%(19/37)、63.4%(26/41)和25.0%(5/20)(P=0.019),Ⅲ~Ⅳ度恶心呕吐发生率分别为32.4%(12/37)、48.8%(20/41)和10.0%(2/20)(P=0.011)。结论同步放化疗用于治疗中晚期子宫颈癌疗效确切,两种化疗方案的疗效及毒性反应无明显差异。
Objective To compare the efficacy and toxicity of cisplatin, docetaxel combined with cisplatin with concurrent chemoradiotherapy and radiotherapy alone in the treatment of advanced cervical cancer. Methods The clinical and pathological data of 98 patients with stage ⅡB ~ ⅢA cervical cancer were retrospectively analyzed. According to the treatment methods, the patients were divided into group A (radiotherapy combined with cisplatin concurrent radiochemotherapy), group B (radiotherapy combined with docetaxel and cisplatin concurrent chemoradiotherapy) and group C (radiotherapy alone). The efficacy and toxicity of the three groups were observed. Results The effective rates of treatment in group A, B and C were 86.5% (32/37), 90.2% (37/41) and 65.0% (13/20), respectively. The differences among the three groups were statistically significant (P = 0.037) . The percentage of grade Ⅲ ~ Ⅳ leukopenia in group A, B and C were 51.4% (19/37), 63.4% (26/41) and 25.0% (5/20) respectively (P = 0.019) The rates of vomiting were 32.4% (12/37), 48.8% (20/41) and 10.0% (2/20), respectively (P = 0.011). Conclusions Simultaneous chemoradiation is effective in treating advanced cervical cancer. There is no significant difference in curative effect and toxicity between the two chemotherapy regimens.