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目的探讨血浆净化治疗在风湿免疫性疾病中的应用。方法选取该院2015年4月一2016年12月收治的42例风湿免疫性疾病患者为研究对象,随机分为对照组21例给予常规药物治疗+血浆吸附技术(PA)治疗,观察组21例给予常规药物治疗+双重滤过血浆净化技术(DFPP)治疗,对比两组治疗效果。结果两组系统性红斑狼疮患者SLEDAI评分、24 h尿蛋白定量、抗ds-DNA抗体等指标明显改善,且观察组改善效果显著高于对照组(P><0.05);观察组风湿性关节炎患者ESR、CRP指标下降程度显著高于对照组(P<0.05)。结论血浆净化技术治疗风湿免疫性疾病效果显著,安全注及有效性更高,具有临床应用价值。
Objective To investigate the application of plasma purification in rheumatic autoimmune diseases. Methods Forty-two patients with rheumatic autoimmune disease admitted from April 2015 to December 2016 in our hospital were randomly divided into control group (n = 21) treated with conventional drug therapy and plasma absorption technique (PA). In the observation group, 21 patients The patients were given conventional medical therapy and double-filtration plasmapheresis (DFPP), comparing the two groups. Results The SLEDAI score, 24 h urine protein quantitation, anti-ds-DNA antibody and other indexes were significantly improved in the two groups of patients with systemic lupus erythematosus, and the improvement effect in the observation group was significantly higher than that in the control group (P> 0.05). The rheumatoid arthritis Patients ESR, CRP index decreased significantly higher than the control group (P <0.05). Conclusion Plasma purification is effective in the treatment of rheumatic autoimmune diseases, with safety note and higher efficacy, which is of clinical value.