论文部分内容阅读
【目的】研究胸腔内注入滑石粉浆的急性反应。【方法】50只新西兰雄性白兔胸腔内接受400mg/kg滑石粉后的6h、1、2、4和7d分成5组作实验观察,另10只作为对照组接受生理盐水。【结果】对照组1d内胸水基本吸收,实验组胸水渗出量在第4d达到高峰,第7d完全吸收。白细胞数明显升高,1d内以中性粒细胞占优势,此后则以淋巴细胞为主。LDH迅速增高,于第2天达高峰。胸膜粘连带在第6小时开始形成,第4天后明显增加。镜下胸膜炎症以第2天最严重,而纤维化则第7天最明显。【结论】滑石粉浆可引起急性胸膜炎症和纤维化,是安全、有效的硬化剂。注入后不必引流。
【Objective】 To study the acute reaction of intrathoracic injection of talcum powder. 【Methods】 50 New Zealand white rabbits were divided into 5 groups at 6h, 1, 2, 4 and 7 days after receiving 400mg / kg talc in the thoracic cavity. The other 10 rabbits as control group received saline. 【Results】 In the control group, the pleural effusion was basically absorbed within 1 day. The amount of pleural effusion in the experimental group peaked on the 4th day and was completely absorbed on the 7th day. The number of white blood cells increased significantly, within 1d to neutrophil dominance, then mainly to lymphocytes. LDH rapidly increased and peaked on the second day. Pleural adhesions began to form at 6 hours and increased significantly after 4 days. Microscopic pleural inflammation is most severe on day 2, whereas fibrosis is most pronounced on day 7. 【Conclusion】 Talcum powder can cause acute pleural inflammation and fibrosis, which is a safe and effective hardener. Do not have to drain after injection.