论文部分内容阅读
研究哈蟆油非水溶性成分及其酶解物的抗氧化作用。采用D-半乳糖法建立小鼠过氧化损伤模型。设立哈蟆油非水溶性成分及其酶解物高、中、低(0.30、0.15、0.075g/kg)3个剂量组和模型对照组、空白对照组,灌胃给药30d。观察过氧化损伤模型小鼠肝组织中丙二醛(MDA)含量、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活力的变化。哈蟆油非水溶性成分可以显著降低肝组织中MDA含量,但对SOD、GSH-Px活力的升高无影响;哈蟆油非水溶性成分酶解物可显著降低丙二醛(MDA)含量,显著增加肝组织GSH-Px、SOD的活力。哈蟆油非水溶成分酶解物具有明显的抗氧化作用。
To study the antioxidant effect of water-insoluble components of Eupatorium tamarense and its hydrolyzate. The mouse model of peroxisome damage was established by D-galactose method. To set up the water-soluble components of Rana oil and its high, medium and low hydrolyzate (0.30,0.15,0.075g / kg) three dose groups and the model control group, blank control group, intragastric administration 30d. To observe the changes of malondialdehyde (MDA) content, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in liver tissue of peroxidative injury model mice. The non-water-soluble components of Rana oil could significantly reduce the content of MDA in liver tissue, but had no effect on the activity of SOD and GSH-Px. The non-water soluble components of Rana nigrifolia reduced the contents of malondialdehyde (MDA) , Significantly increased the activity of GSH-Px and SOD in liver tissue. Oviductus aquatica hydrolyzate has obvious anti-oxidant effect.