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医药工业上常采用镍或铂类金属作为催化剂,但由于前者易燃,后者价格较高,因之不能广泛应用。苏联“全苏化学药物研究所”研究成功了一种不着火的镍催化剂(H.H.K.)。它是碳酸镍或甲酸镍在联苯、二苯基乙烷、二苯基醚、石腊或凡士林中于240～250℃分解制得。其活性取决于分解条件。在180～220℃分解得到的活性低,在275℃以上得到的是易着火的催化剂。催化剂中的石腊含量对其活性也有影响。如果催化剂中含有多量石腊,氢化就进行得慢;含有10～15%石腊时,活性最大。H.H.K的还原速度与氢的压力成正比,在温度低于80℃时还原实际上不进行。H.H.K.制备较易,可以代替雷尼镍,适用于硝基及酮基的还原,以及醛基的还原氨基化。且用后可以再生。长期貯放仍具有活性。如将其制成铜·镍催化
The pharmaceutical industry often uses nickel or platinum metal as a catalyst, but because of the former flammable, the latter higher prices, it can not be widely used. The Soviet “All Su Institute of Chemical and Pharmaceutical Research” succeeded in a non-fire nickel catalyst (H.H.K.). It is nickel carbonate or nickel formate in biphenyl, diphenyl ethane, diphenyl ether, paraffin or petrolatum at 240 ~ 250 ℃ decomposition of the system. Its activity depends on the conditions of decomposition. The activity obtained by the decomposition at 180 to 220 ° C is low, and at about 275 ° C or more, the easily ignitable catalyst is obtained. The paraffin content in the catalyst also has an effect on its activity. If the catalyst contains a large amount of paraffin, hydrogenation carried out slowly; containing 10 to 15% paraffin, the activity of the largest. The reduction rate of H.H.K is proportional to the pressure of hydrogen, and the reduction is practically not performed at temperatures below 80C. H.H.K. Preparation easier, can replace Raney nickel, suitable for the reduction of nitro and keto, and reductive amination of aldehyde. And after use can be renewable. Long-term storage is still active. If made of copper nickel catalytic