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目的临床观察矽肺合并慢性阻塞性肺疾病(COPD)急性发作期患者应用糖皮质激素(ICS)和长效受体激动剂(LABA)联合吸入治疗对肺功能的影响。方法 61例矽肺合并慢性阻塞性肺疾病急性发作期患者随机分为观察组和对照组。观察组(31例)在常规消炎祛痰的同时给予ICS/LABA混合吸入剂(舒利迭)吸入,每次50μg/500μg,2次/d;对照组(30例)给予常规消炎祛痰治疗。两组疗程均为20 d。对比两组治疗前后肺功能变化。结果 61例患者全部完成本试验。两组肺功能在治疗前后均有明显变化。治疗后FEV1/FVC和FEV 1%预计值观察组高于对照组,差异有统计学意义(P<0.05)。结论矽肺合并COPD急性发作期患者联合吸入ICS和LABA能明显改善肺功能,减轻症状,提高生活质量。
Objective To observe the effect of combined inhalation of glucocorticoid (ICS) and long-acting receptor agonist (LABA) on pulmonary function in patients with silicosis complicated with chronic obstructive pulmonary disease (COPD). Methods A total of 61 patients with silicosis complicated with chronic obstructive pulmonary disease were randomly divided into observation group and control group. The observation group (n = 31) was given ICS / LABA inhalation (50mg / 500μg, twice daily) at the same time of routine antiphlogistic and expectorant treatment. The control group (30 cases) were given routine antiphlogistic and expectorant treatment . The two courses of treatment were 20 d. The changes of lung function in two groups before and after treatment were compared. Results 61 patients completed the test. Two groups of lung function before and after treatment were significantly changed. After treatment, FEV1 / FVC and FEV 1% of the expected value of the observation group was higher than the control group, the difference was statistically significant (P <0.05). Conclusion Combined inhalation of ICS and LABA in patients with silicosis and acute exacerbation of COPD can significantly improve lung function, relieve symptoms and improve quality of life.