分别测定１２例新生儿急性肾功衰竭（ＡＲＦ）、２５例非ＡＲＦ和２７例正常新生儿血、尿纤维蛋白降解产物（ＦＤＰ）、血浆内皮素（ＥＴ）和Ｄ二聚体（ＤＤｉｍｅｒ，ＤＤ）。结果：ＡＲＦ组ＦＤＰ较非ＡＲＦ组和正常对照组明显增加（Ｐ＜００１）；ＡＲＦ组ＥＴ、ＤＤ较非ＡＲＦ组明显增加；ＡＲＦ组的肾功能改变（ＢＵＮ、Ｃｒ）与ＦＤＰ、ＥＰ、ＤＤ无显著相关关系。提示血管内和／或肾内凝血是ＡＲＦ的重要因素，血管内皮细胞及肾上皮细胞释放ＥＴ增加，从而影响新生儿ＡＲＦ时水电解质的代谢。 Twelve newborns with acute renal failure (ARF), 25 non-ARF and 27 normal newborn blood, urinary fibrin degradation products (FDP), plasma endothelin (ET), and D-dimer , DD). Results: The FDP of ARF group was significantly higher than that of non-ARF group and normal control group (P <001); the ET and DD of ARF group were significantly increased compared with non-ARF group; the changes of renal function (BUN and Cr) , DD no significant correlation. It is suggested that intravascular and / or intrarenal coagulation is an important factor of ARF. The release of ET from vascular endothelial cells and renal epithelial cells will increase the metabolism of water and electrolyte in newborn ARF.