论文部分内容阅读
目的研究流感大流行阶段应急接种人用禽流感疫苗不良事件监测的有效模式。方法以季节性流感疫苗模拟人用禽流感疫苗,在北京、江苏选取6个门诊接种共1218例,采用主动监测与被动监测相结合的方法开展集中接种疫苗后不良事件监测研究。结果收集不良事件报告36例;成人组报告数量最多,老年组报告数量最少;北京、江苏农村被动监测门诊均没有自愿报告;不良事件多为一般反应;各级疾病预防控制中心与药品不良反应监测机构建立了信息沟通交流机制。结论主动与被动相结合的监测模式,重点开展农村宣传教育活动,以及尽快建立各级疾病预防控制中心与药品不良反应监测机构的常规工作交流机制,均将促进应急状态下疫苗不良事件监测工作的开展。
Objective To study the effective mode of surveillance of adverse events in people vaccinated with human avian influenza vaccine during the influenza pandemic phase. Methods A total of 1218 outpatients were vaccinated with a seasonal flu vaccine against human bird flu in Beijing and Jiangsu Provinces. A combination of active surveillance and passive surveillance was used to monitor surveillance of adverse events after intensive vaccination. Results A total of 36 cases of adverse events were collected. The largest number was reported in the adult group and the lowest was reported in the elderly group. There were no voluntary reports in the passive surveillance clinics in rural areas in Beijing and Jiangsu Provinces. Most of the adverse events were general reactions. The Centers for Disease Control and Prevention Institutions have established a mechanism for information exchange. Conclusions The combination of active and passive monitoring modes, focusing on rural publicity and education activities, as well as establishing as soon as possible a mechanism for the exchange of routine work between disease prevention and control centers and adverse drug reaction monitoring agencies at all levels will promote the monitoring of vaccine adverse events in emergency situations Carry out.