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G蛋白偶联受体家族卵巢癌G蛋白偶联受体1(ovarian cancer G protein-coupled receptor 1,OGR1)亚家族的OGR1、T细胞死亡偶联基因8(T-cell death associated gene 8,TDAG8)、G蛋白偶联受体4(G protein-coupled receptor 4,GPR4)及诱导细胞停滞于G2/M期的G蛋白偶联受体G2A(from G2 accumulation)4种受体是最新发现的一类质子感知受体.除了质子,体内又有它们各自特定的脂质分子配体活化这些受体来调节细胞机能.该类受体广泛分布于人的各种正常组织和肿瘤组织细胞中,在肿瘤的发生与转移、细胞骨架重组等生理病理过程中发挥双重作用.正常表达时它们有一定的抑制肿瘤作用,但这些受体的异常表达或过表达使某些组织和细胞恶性转化,导致肿瘤的发生.本文综述了在肿瘤组织的酸性微环境中,细胞表达的质子(pH)感知受体对肿瘤发生与肿瘤转移的调节作用及其相关的信号通路.
T-cell death associated gene 8 (TDAG8), an OGR1 subfamily of G protein-coupled receptor family Ovarian cancer G protein-coupled receptor 1 (OGR1) ), G protein-coupled receptor 4 (GPR4) and G-cell-coupled receptor G2A (G2 arresting cells in G2 / M phase) were the most recently discovered Like protons, in addition to protons, they have their own specific ligands for lipid molecules that activate these receptors to regulate cellular functions, which are widely distributed in various human normal tissues and tumor cells Tumorigenesis and metastasis, cytoskeletal reorganization and other physiological and pathological processes play a dual role.In normal expression, they have a certain inhibitory effect on the tumor, but the abnormal expression of these receptors or over-expression of certain tissues and cells malignant transformation, leading to tumors This review summarizes the regulatory role of proton expressed receptors on tumorigenesis and tumor metastasis and their related signaling pathways in the acidic microenvironment of tumor tissues.