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目的:探讨不同三联疗法根除幽门螺杆菌(Hp)的疗效。方法:选取238例于2015年6月至2015年12月广州市白云区第三人民医院接收的消化性溃疡患者,将入选者随机分为克拉霉素组(n=119)与呋喃唑酮组(n=119),呋喃唑酮组给予奥美拉唑+左氧氟沙星+呋喃唑酮治疗,克拉霉素组给予奥美拉唑+甲硝唑+克拉霉素治疗,观察两组治疗效果、Hp根除率及相关指标情况。结果:治疗后,呋喃唑酮组临床疗效、Hp根除率较克拉霉素组患者更佳,且复发率低于克拉霉素组,差异均具有统计学意义(P<0.05);呋喃唑酮组患者腹痛消失时间、溃疡愈合时间均较克拉霉素组短,差异具有统计学意义(P<0.05);两组治疗后,腹痛、嗳气、腹胀、反酸症状积分均明显降低,其中呋喃唑酮组降低幅度更显著,差异具有统计学意义(P<0.05)。结论:幽门螺杆菌阳性消化性溃疡采用奥美拉唑+左氧氟沙星+呋喃唑酮治疗方案,可提高疗效及幽门螺杆菌根治率,且安全性相对较高,优于传统治疗方案。
Objective: To investigate the efficacy of different triple therapy in eradicating Helicobacter pylori (Hp). Methods: A total of 238 patients with peptic ulcer were enrolled in the Third People’s Hospital of Guangzhou Baiyun District from June 2015 to December 2015. The patients were randomly divided into clarithromycin group (n = 119) and furazolidone group (n = 119). The furazolidone group was treated with omeprazole + levofloxacin + furazolidone. Omeprazole + metronidazole + clarithromycin was given to the clarithromycin group. The therapeutic effect, eradication rate of Hp and related indicators were observed. Results: The curative effect and Hp eradication rate of furazolidone group were better than those of clarithromycin group after treatment, and the relapse rate was lower than that of clarithromycin group (P <0.05). The time of disappearance of abdominal pain in furazolidone group , Ulcer healing time were shorter than the clarithromycin group, the difference was statistically significant (P <0.05); two groups after treatment, abdominal pain, belching, bloating, acid reflux symptom scores were significantly lower, of which the furazolidone group decreased more significantly, The difference was statistically significant (P <0.05). Conclusion: The treatment of positive H.pylori-positive peptic ulcer with omeprazole + levofloxacin + furazolidone can improve curative effect and cure rate of Helicobacter pylori, and its safety is relatively higher than traditional treatment.