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目的:探讨创伤性颅脑外伤患者脑脊液中代谢谱的改变及其临床意义。方法:用高分辨率质子核磁共振代谢组学检验创伤性颅脑损伤对脑化学物质和代谢的影响。在重型创伤性颅脑损伤组(n=6),损伤后的脑脊液分析脑代谢的变化,并与轻,中型颅脑损伤组(n=6)相比较。结果:与轻型,中型颅脑损伤组相比,发现了乙酰乙酸,尿酸,3-硝基酪氨酸升高的证据。3组脑脊液中乙酰乙酸,尿酸,3-硝基酪氨酸含量有显著性差异(p<0.01)。结论:颅脑创伤后脑脊液中乙酰乙酸,尿酸,3-硝基酪氨酸值均有不同程度升高,且升高越明显则病情越严重。说明乙酰乙酸,尿酸,3-硝基酪氨酸可作为颅脑创伤病情的监测指标。
Objective: To investigate the changes of the metabolic profile in cerebrospinal fluid of patients with traumatic brain injury and its clinical significance. Methods: The effects of traumatic brain injury on brain chemistry and metabolism were examined by high resolution proton nuclear magnetic resonance metabonomics. In the severe traumatic craniocerebral injury group (n = 6), cerebrospinal fluid after injury was analyzed for changes in brain metabolism and compared with light and medium craniocerebral injury groups (n = 6). RESULTS: Evidence of increased acetoacetate, uric acid, and 3-nitrotyrosine was found in comparison with light and medium craniocerebral injury groups. The contents of acetoacetate, uric acid and 3-nitrotyrosine in CSF of 3 groups were significantly different (p <0.01). Conclusion: Cerebrospinal fluid (CSF) acetylacetate, uric acid and 3-nitrotyrosine increased in varying degrees in patients with traumatic brain injury, and the more severe the disease was, the more severe the disease was. Description of acetoacetate, uric acid, 3-nitrotyrosine can be used as a monitoring indicator of traumatic brain injury.