目的探讨地塞米松治疗突发性聋的临床疗效。方法将256例(287耳)突发性聋患者随机分为地塞米松组和常规组,地塞米松组131例(147耳)应用地塞米松、常规药物和高压氧治疗,常规组125例(141耳)仅应用常规药物和高压氧治疗,一个疗程10 d,于治疗后第11天和第21天对两组疗效进行评价。结果治疗后第11天和第21天,地塞米松组的疗效均优于常规组,差异有统计学意义(P<0.05)。结论地塞米松对突发性聋具有确切的疗效,值得临床推广应用。 Objective To investigate the clinical effect of dexamethasone in treating sudden deafness. Methods 256 patients (287 ears) with sudden deafness were randomly divided into dexamethasone group and conventional group. Dexamethasone group (n = 131) was treated with dexamethasone, conventional drugs and hyperbaric oxygen therapy, and 125 cases (141 ears) only using conventional drugs and hyperbaric oxygen therapy, a course of 10 days, on the 11th and 21st after treatment, the two groups were evaluated. Results The efficacy of dexamethasone group was better than that of the conventional group on the 11th and 21st days after treatment (P <0.05). Conclusion Dexamethasone has definite curative effect on sudden deafness and deserves clinical application.