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甲胎蛋白(AFP)检测以诊断肝细胞癌早已为人们所熟知,但对慢性 HBV 感染者定期作AFP 随访以早期发现肝细胞癌的前瞻性研究报道甚少。作者等对290例慢性 HBV 感染者,包括男203例,女87例,年龄为7～74岁,每3～6个月作肝功能、AFP(正常<20ng/ml)和乙肝血清学检测,共随访12～50个月(平均27个月)以了解非恶性肝病者 AFP 升高的频度、型式和 AFP 检测对早期发现肝细胞癌的价值。如 AFP 仍升高即作 B 超检查,并每隔2～4周复查,如 AFP 持续升高2个月以上,而ALT(正常<40u/1)无明显增高,或 AFP 进
AFP test has long been known to diagnose hepatocellular carcinoma. However, there are few reports of prospective studies on the early detection of hepatocellular carcinoma in AFP patients with chronic HBV infection. The author of 290 cases of chronic HBV infection, including 203 males and 87 females, aged 7 to 74 years old, every 3 to 6 months for liver function, AFP (normal <20ng / ml) and hepatitis B serology, A total of 12 to 50 months (mean 27 months) were followed up to investigate the frequency and type of AFP in non-malignant liver disease and the value of AFP in early detection of hepatocellular carcinoma. If AFP is still elevated for B-ultrasound, and reviewed every 2 to 4 weeks, such as AFP continued to rise more than 2 months, while ALT (normal <40u / 1) no significant increase, or AFP into