甾体激素作用的经典概念认为,在发挥生物学作用之前,瑙体激素必须首先与其细胞内的特异性受体结合。丹那唑是一种合成的甾体,已证明它能与实验动物和人类的多种细胞内的甾体激素(雄激索、雌激素、孕激素)的受体相结合。也曾有人评价过丹那唑与人子宫内膜中的胞浆雄激素受体、雌激素受体以及孕激素受体的相互作用。此外,丹那唑也能结合于动物血清中的皮质结合球蛋白和性激素结合球蛋白。为进一步阐明丹那唑的药理学特性及作用机制,本文研究了在人子宫内膜,丹那唑对多种蛋白质结合的取代作用。从子宫全切术的样品得到人子宫内膜,经匀浆,离心,取上清得胞浆部分。将一定量的胞浆部 The classical concept of the role of steroid hormones suggests that, before exerting a biological effect, the hormone of the nao body must first bind to its specific receptors within the cell. Danazol is a synthetic steroid that has been shown to bind to the receptors of steroid hormones (soma, estrogen, and progestin) in a variety of cells in laboratory animals and humans. There have also been evaluations of the interaction of Danazol with cytoplasmic androgen receptor, estrogen receptor, and progestin receptor in human endometrium. In addition, Danazol also binds to cortical-binding globulin and sex hormone-binding globulin in animal serum. In order to further elucidate the pharmacological properties of Danazol and its mechanism of action, this paper studies the substitution effect of Danazol on various protein binding in human endometrium. Human uterine endometrium was obtained from the sample of hysterectomy. After homogenization and centrifugation, the supernatant was harvested into the cytoplasm. Will be a certain amount of cytoplasm