以氰基取代的芳环化合物为起始原料,采用一锅法经加成、缩合、闭环3步反应合成了6个2-芳环取代咪唑化合物。同时考察了反应过程中甲醇钠用量、闭环反应温度和反应时间对目标产物收率的影响,得到的最佳反应条件:n(甲醇钠)∶n(氰基化合物)=(0.08～0.12)∶1,反应温度80～90℃,反应时间3～8 h。产物结构通过熔点、核磁、质谱、元素分析进行了确证。 Cyclic substituted aromatic compounds were used as starting materials to synthesize six 2-aryl substituted imidazole compounds by one-pot addition, condensation and ring-closure reactions. At the same time, the effects of sodium methoxide dosage, ring closure temperature and reaction time on the yield of the target product were investigated. The optimal reaction conditions were as follows: n (sodium methoxide): n (cyano compound) = (0.08-0.12) 1, reaction temperature 80 ~ 90 ℃, reaction time 3 ~ 8 h. The structure of the product was confirmed by melting point, NMR, MS and elemental analysis.