对疟疾免疫的复杂性众所周知,然而抗疟疾免疫保护作用的明确的相关物还没有建立。如果能对疟疾疫苗候选物诱导的免疫标志物有更好的了解,则可大大有助于疫苗的开发、免疫原性的监测和疫苗现场效力的评估。作者曾报告过,用数种疫苗方案在牛津未接触过疟疾的健康受试者中,抗子孢子试验性攻击的完全的保护效力或部分保护效力。疫苗方案包括使用RTS,S/AS02A和改进的表达CSP The complexities of immunization against malaria are well known, yet there is no clear correlation between anti-malarial immunoprotective effects. A better understanding of immunological markers induced by malaria vaccine candidates can greatly assist in vaccine development, monitoring of immunogenicity and assessment of vaccine field efficacy. The authors have reported complete protective or partial protective efficacy against experimental challenge with sporozoites in several healthy vaccinated subjects who had not been exposed to malaria in Oxford using several vaccine regimens. Vaccine protocols include the use of RTS, S / AS02A and improved expression of CSP