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目的 :进一步研究脑血管痉挛的发生机理 ,为临床治疗服务。方法 :采用 1 4只成年家犬 ,实验组 9只 ,对照组 5只 ,通过 2次枕大池注血法建立蛛网膜下腔出血 (SAH)模型。观察痉挛血管的自由基变化、血管活性、血管造影像、超微结构变化。另外 2 0只犬用来观察血管扩张剂的作用。结果 :实验组较对照组自由基含量高 ,血管活性降低 ,血管狭窄 ,管壁损害重。结论 :尼莫地平对急性痉挛有效 ,对慢性痉挛无效 ;慢性血管痉挛是以管壁结构性狭窄为特点。
Objective: To further study the pathogenesis of cerebral vasospasm for clinical treatment services. Methods: 14 adult dogs, 9 experimental group and 5 control group were established. Subarachnoid hemorrhage (SAH) model was established by two occipital cistern injection methods. Observation of spastic blood vessels free radical changes, vasoactivity, angiography, ultrastructural changes. Another 20 dogs were used to observe the effects of vasodilators. Results: Compared with the control group, the experimental group had high free radical content, decreased vasoconstriction, narrowed blood vessels and severely damaged wall. Conclusion: Nimodipine is effective in treating acute spasm and has no effect on chronic spasm. Chronic vasospasm is characterized by structural narrowing of the wall.