0　引言受某些肿瘤患者在感染病毒后出现自发性肿瘤缓解这一现象的启发,早在上个世纪初便有溶瘤病毒治疗的研究[1] 。腺病毒发现后不久也曾被用来治疗头颈部恶性肿瘤,注射腺病毒后肿瘤有不同程度缩小,但治疗后肿瘤易复发,效果难以持久;直到1996年,Bischoff等[2 ] 首次报道去除 0 Introduction Inspired by the phenomenon of spontaneous tumor remission in some cancer patients after infection with the virus, as early as the early last century, there was an oncolytic treatment [1]. Shortly after the discovery of adenovirus, it was also used to treat head and neck malignant tumors. After adenovirus injection, the tumors were reduced to varying degrees, but the tumors were easy to recur after treatment. Bispeckers et al. [2] first reported removal in 1996