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目的:评价α-细辛脑注射液辅助治疗对哮喘患儿血清中COX-2、IL-8、IgE水平的影响及其临床疗效。方法:选取我院哮喘患儿96例,随机分为实验组和对照组,各48例,对照组采用常规药物治疗,实验组在此基础上加用α-细辛脑注射液,观察患儿的临床症状并测量血清中COX-2、IL-8、Ig E含量的变化情况。结果:实验组有效率明显高于对照组,差异具有统计学意义(x2=5.352,P=0.0207);实验组喘息、呼吸困难、胸闷、咳嗽及哮鸣音等临床症状的消失时间明显低于对照组,差异均具有统计学意义(P<0.05);实验组治疗后血清COX-2、IL-8及Ig E因子含量显著低于对照组,差异均具有统计学意义(P<0.05)。结论:α-细辛脑注射液辅助治疗哮喘的疗效显著,能够降低患儿血清COX-2、IL-8及Ig E水平。
Objective: To evaluate the effect of α-Asarone Injection adjuvant therapy on serum COX-2, IL-8 and IgE in children with asthma and its clinical efficacy. Methods: Ninety-six children with asthma in our hospital were randomly divided into experimental group and control group, 48 cases in each group. The control group was treated with conventional drugs. On the basis of this, the experimental group was given α-Asarone Injection, The clinical symptoms and measurement of serum COX-2, IL-8, IgE content changes. Results: The effective rate of the experimental group was significantly higher than that of the control group (x2 = 5.352, P = 0.0207). The disappearance time of the clinical symptoms such as wheezing, dyspnea, chest tightness, cough and wheezing in the experimental group was significantly lower than that in the control group (P <0.05). The levels of COX-2, IL-8 and Ig E in the experimental group were significantly lower than those in the control group (P <0.05). Conclusion: Asarixin injection is effective in the treatment of asthma, which can reduce the serum levels of COX-2, IL-8 and IgE in children.