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目的:观察中药化癥消胚汤辅助治疗异位妊娠的临床疗效。方法:将符合标准的74例患者随机分为两组,对照组40例采用米非司酮和甲氨蝶呤治疗,观察组34例在对照组基础上加用中药化癥消胚汤辅助治疗。结果:观察组30例患者治愈,治愈率88.24%,2例患者血β-HCG值增高,2例患者出现妊娠破裂手术治疗。对照组32例患者治愈,治愈率80.00%,8例患者血β-HCG值增高,5例患者出现妊娠破裂手术治疗。两组比较,治愈率差异无统计学意义(P>0.05)。观察组血β-HCG恢复正常、异位包块消失、月经恢复和治愈时间均快于对照组。组间比较,差异均有统计学意义(P<0.05)。治疗后两组ESCA、HAMA、HAMD和NRS评分均降低,组间比较,差异有显著统计学意义(P<0.05)。观察组和对照组患者均出现不同程度不良反应,总发生率分别为29.41%、35.00%。组间比较,差异无显著统计学意义(P>0.05)。结论:米非司酮和甲氨蝶呤联合中药化癥消胚汤辅助治疗异位妊娠,可加快治愈时间,改善患者自我护理能力和负面情绪,疗效安全可靠。
Objective: To observe the curative effect of traditional Chinese medicine Xiao Yu Decoction adjuvant treatment of ectopic pregnancy. Methods: A total of 74 eligible patients were randomly divided into two groups. The control group was treated with mifepristone and methotrexate. In the observation group, 34 cases were treated with the adjuvant chemotherapy with Xiaozheng Decoction . Results: In the observation group, 30 patients were cured. The cure rate was 88.24%. The blood β-HCG level increased in 2 patients and surgically ruptured in 2 patients. The control group of 32 patients were cured, the cure rate was 80.00%, 8 patients with elevated serum β-HCG value, 5 patients with pregnancy rupture surgery. There was no significant difference in cure rate between the two groups (P> 0.05). The observation group blood β-HCG returned to normal, ectopic mass disappeared, menstrual recovery and healing time were faster than the control group. The differences between the two groups were statistically significant (P <0.05). ESCA, HAMA, HAMD and NRS scores decreased in both groups after treatment, with significant differences between the two groups (P <0.05). Patients in observation group and control group all showed different degrees of adverse reactions, the total incidence rates were 29.41% and 35.00% respectively. There was no significant difference between groups (P> 0.05). Conclusion: Combination of mifepristone and methotrexate in combination with Chinese herbal medicine Xiaozhu decoction in the treatment of ectopic pregnancy can speed up the healing time, improve the self-care ability and negative emotions of patients, and the curative effect is safe and reliable.