癌性恶病质病人存在着严重的代谢紊乱 ,肿瘤释放特异性的恶病质因子以及机体细胞因子合成增加 ,导致宿主分解代谢增强、合成代谢减少 ,能量消耗增加 ,从而使机体储存的脂肪和蛋白质进行性消耗 ,器官功能活性下降 ,最终导致全身衰竭。通过对癌性恶病质发病机制的不断了解 ,以发病机制为基础的治疗药物的应用将对癌性恶病质的治疗产生深远的影响 Patients with cancerous cachexia have serious metabolic disorders, tumor-specific cachexia factors and increased synthesis of cytokines, leading to enhanced host catabolism, reduced anabolism, increased energy expenditure, and consequent consumption of stored body fat and protein , Organ function decline, eventually leading to systemic failure. Through the continuous understanding of the pathogenesis of cancerous cachexia, the use of therapeutic agents based on pathogenesis will have a profound impact on the treatment of cancerous cachexia