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目的探讨红细胞分布宽度(RDW)、C-反应蛋白(CRP)和癌胚抗原(CEA)联合检测在结肠癌诊断和治疗中的临床价值。方法收集90例结肠癌患者(结肠癌组)和90例正常对照者(对照组)的血液标本,应用罗氏全自动免疫分析仪检测血清CRP和CEA含量,使用迈瑞BC-6900血细胞分析仪测定RDW。结果结肠癌组患者RDW、CRP和CEA含量均高于对照组,差异有统计学意义(P<0.05)。RDW、CRP和CEA联合检测的灵敏度和诊断符合率分别为81.0%和84.0%。结论联合检测RDW、CRP和CEA可提高结肠癌患者诊断的敏感性和诊断符合率,对早期发现、诊治结肠癌具有重要的临床意义。
Objective To investigate the clinical value of combined detection of RDW, CRP and CEA in the diagnosis and treatment of colon cancer. Methods Blood samples of 90 patients with colon cancer (colon cancer group) and 90 healthy controls (control group) were collected. Serum CRP and CEA levels were detected by Roche autoimmunoassay, and the RDW was detected by Mindray BC-6900 hematology analyzer . Results The levels of RDW, CRP and CEA in colon cancer patients were significantly higher than those in control group (P <0.05). The sensitivities and diagnostic coincidence rates of RDW, CRP and CEA were 81.0% and 84.0% respectively. Conclusions Combined detection of RDW, CRP and CEA can increase the sensitivity of diagnosis and the coincidence rate of diagnosis in patients with colon cancer, which has important clinical significance for early detection, diagnosis and treatment of colon cancer.