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目的:研究双歧杆菌三联活菌片对溃疡性结肠炎患者免疫功能及Fas/FasL表达的影响。方法:选取2014年7月至2015年6月本院收治的84例溃疡性结肠炎患者,根据患者入院顺序分为观察组(42例)和对照组(42例)两组。对照组采取美沙拉秦肠溶片进行治疗,观察组在此基础上结合双歧杆菌三联活菌片进行治疗。分析两组患者治疗前和治疗2个月后炎症因子水平、T细胞亚群以及Fas/FasL表达情况,并比较两组患者的临床疗效。结果:观察组总的有效率显著高于对照组(P<0.05)。治疗后,观察组的血清白介素-1(IL-1)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平显著低于对照组(P<0.05),CD4+、CD4+/CD8+T细胞亚群显著高于对照组,CD8+、Fas/FasL表达显著低于对照组,差异均有统计学意义(P<0.05)。结论:使用双歧杆菌三联活菌片治疗溃疡性结肠炎患者能改善患者的免疫功能及Fas/Fasl表达,减轻炎症反应,临床效果良好。
OBJECTIVE: To study the effect of Bifidobacterium triple viable tablet on immune function and Fas / FasL expression in patients with ulcerative colitis. Methods: A total of 84 patients with ulcerative colitis admitted to our hospital from July 2014 to June 2015 were divided into observation group (n = 42) and control group (n = 42) according to the admission order. In the control group, Mesalazine enteric-coated tablets were taken for treatment. On the basis of this, the observation group was treated with Bifidobacterium triple active viable tablets. The level of inflammatory cytokines, T lymphocyte subsets and Fas / FasL expression in two groups before and after treatment for two months were analyzed. The clinical efficacy of the two groups was compared. Results: The total effective rate in observation group was significantly higher than that in control group (P <0.05). After treatment, the levels of serum IL-1, IL-6, IL-8 and TNF-α in the observation group were significantly lower than those in the control group (P <0.05). The levels of CD4 + and CD4 + / CD8 + T cells were significantly higher than those in the control group. The expressions of CD8 + and Fas / FasL were significantly lower than those in the control group (P <0.05). Conclusion: The treatment of patients with ulcerative colitis with Bifidobacterium triple active viable tablets can improve immune function and Fas / Fasl expression in patients with inflammatory reaction and has good clinical effect.