论文部分内容阅读
以L-苯丙氨酸为亲水部分和1,8-辛二胺为疏水部分,通过酯化生成酰胺和HCl脱去BOC保护基两步反应,合成一种新型Bola型表面活性剂N,N′-二苯丙氨酸酰基-1,8-辛二胺(DAOPh),采用IR、质谱和~1H NMR对其结构进行了表征.应用酸碱滴定法测得其pKa,采用电导率法、表面张力和芘荧光探针法测定了DAOPh水溶液的临界胶束浓度(CMC),进而预测其在水溶液中的聚集行为,探讨其作为药物载体的潜在优势.
L-phenylalanine as a hydrophilic part and 1,8-octanediamine as a hydrophobic part, esterification to generate amide and HCl off BOC protective group two-step reaction to synthesize a new type Bola surfactant N, N’-diphenylalanine-1,8-octanediamine (DAOPh) was synthesized and its structure was characterized by IR, mass spectra and 1H NMR.The pKa was measured by acid-base titration, , Surface tension and pyrene fluorescence probe method to determine the critical micelle concentration (CMC) of DAOPh aqueous solution, and then to predict its aggregation behavior in aqueous solution, to explore its potential advantages as a drug carrier.