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目的 探讨氨甲酰血红蛋白（ Ｃａｒ Ｈｂ） 在急、慢性肾衰中的诊断价值。方法 用高效液相色谱法测定健康对照组３６ 例，急性肾衰１０ 例，慢性肾衰５１ 例患者 Ｃａｒ Ｈｂ 含量。按肾衰程度将慢性肾衰（ Ｃ Ｒ Ｆ） 分为轻度、中度和重度３ 个亚组，将３ 组 Ｃａｒ Ｈｂ 含量与 Ｂ Ｕ Ｎ、 Ｓｃｒ 作相关性分析。结果 与对照组 Ｃａｒ Ｈｂ 含量［（３０ ．０ ±６ ．１）μｇ Ｃ Ｖ／ｇ Ｈｂ］ 比较，急性肾衰组 Ｃａｒ Ｈｂ 含量显著升高，但显著低于慢性肾衰组［（６７ ．４ ±２３ ．２） 和（１３９ ．９ ±５２ ．０）μｇ Ｃ Ｖ／ｇ Ｈｂ ， Ｐ＜ ０ ．０１］ 。急性肾衰组 Ｃａｒ Ｈｂ 与 Ｂ Ｕ Ｎ、 Ｓｃｒ 相关不显著；所有急性肾衰病例 Ｃａｒ Ｈｂ 均≤１０５ ．０μｇ Ｃ Ｖ／ｇ Ｈｂ ， Ｃａｒ Ｈｂ／ Ｂ Ｕ Ｎ≤３ ．５ ， Ｃａｒ Ｈｂ／ Ｓｃｒ ≤０ ．１５ 。慢性肾衰组 Ｃａｒ Ｈｂ 与 Ｂ Ｕ Ｎ 及 Ｓｃｒ 成正比。结论 测定 Ｃａｒ Ｈｂ 是鉴别急慢性肾衰的有用指标，并能反映慢性肾衰程度。
Objective To investigate the diagnostic value of carbamoyl hemoglobin (Carb) in acute and chronic renal failure. Methods The contents of Car Hb in 36 healthy controls, 10 acute renal failure patients and 51 chronic renal failure patients were determined by high performance liquid chromatography (HPLC). Chronic renal failure (C R F) was divided into mild, moderate and severe subgroups according to the degree of renal failure. The correlation between Car Hb and B U N and Scr was analyzed. Results Compared with the control group CarHb content [(30.0 ± 6.1) μg C V / g Hb], CarHb levels were significantly increased in acute renal failure group, but significantly lower than that in chronic renal failure group [(67.4 ± 23 .2) and (139 .9 ± 52 .0) μg C V / g Hb, P <0. 01]. There was no significant correlation between Car Hb and B U N, Scr in acute renal failure group, Car Hb in all acute renal failure cases was less than or equal to 105. 0 μg C V / g Hb, Car Hb / B U N ≦ 3. 5, Car Hb / Scr ≤0. 15. Car Hb in chronic renal failure group is proportional to B U N and Scr. Conclusion The determination of Car Hb is a useful indicator of acute and chronic renal failure, and can reflect the degree of chronic renal failure.