本文分析320例初治肺结核病人,单用抗结核药物与并用山莨菪碱,对肝损害影响的比较.结果显示,抗结核药组168例,肝受损27例,损害率为16%(27/168),与国内外报道颇为一致;并用山莨菪碱组152例,肝受损9例,损害率为6%(9/152),后者明显低于前者(P<0.05).结果表明,并用山莨菪碱治疗肺结核,使抗结核药引起肝损害明显减少. This article analyzes 320 patients with newly diagnosed tuberculosis patients, single use of anti-tuberculosis drugs and anisodamine, the impact of liver damage comparison results show that 168 cases of anti-TB drugs, liver damage in 27 cases, the damage rate was 16% (27 / 168), which was consistent with the reports at home and abroad. There were 152 cases with anisodamine and 9 cases with liver damage, the damage rate was 6% (9/152), which was significantly lower than the former (P <0.05) .Results That, and the use of anisodamine in the treatment of pulmonary tuberculosis, anti-tuberculosis drugs cause liver damage was significantly reduced.