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目的:探讨血小板聚集功能在缺血性脑血管病(ICVD)发病中作用。方法:对发病72h内的ICVD患者72例以及40名健康对照者进行血小板最大聚集率(MAR)、血浆血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)、P-选择素水平和血清血小板活化因子(PAF)水平以及血小板膜糖蛋白(GP)Ⅲa的基因PLA多态性检测。结果:ICVD患者血小板MAR以及血TXB2、TXB2/6-keto-PGF1α比值、P-选择素和PAF水平均显著高于对照者(P<0.05),所有受试者GPⅢa基因型均为PLA1/A1纯合基因型,未发现该位点碱基变异。结论:ICVD患者急性期血小板活化功能增强、聚集性增加,但此与血小板GPⅢ基因PLA多态性无关。
Objective: To investigate the role of platelet aggregation in the pathogenesis of ischemic cerebrovascular disease (ICVD). Methods: The maximum platelet aggregation rate (MAR), plasma TXB2, 6-keto-PGF1α, P - selectin and serum platelet activating factor (PAF) levels and PLA gene polymorphism of platelet membrane glycoprotein (GP) Ⅲa. Results: The levels of platelet MAR, TXB2, TXB2 / 6-keto-PGF1α, P-selectin and PAF in ICVD patients were significantly higher than those in controls (P <0.05). The genotypes of GPⅢa in all subjects were PLA1 / A1 Homozygous genotype, found no mutation at this site. CONCLUSION: Platelet activation in ICVD patients is enhanced during acute phase, but their aggregation is not correlated with platelet GP Ⅲ gene polymorphism.