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研究了阿魏酸钠对犬心脏停跳１０分钟复苏后４小时脑组织中血栓素Ｂ２（ＴＸＢ２）、６－酮－前列腺素Ｆ１ａ（６－ｋｅｔｏ－ＰＧＦ１ａ）及丙二醛（ＭＤＡ）含量的影响。１７只犬随机分为非缺血对照组（Ａ组）、缺血再灌注常规治疗组（Ｂ组）及缺血再灌注阿魏酸钠治疗组（Ｃ组）。结果发现，Ｂ组ＴＸＢ２、ＭＤＡ含量及ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１ａ比值均较 Ａ组明显升高（Ｐ＜０． ０１）。 Ｃ组 ＴＸＢ２、ＭＤＡ含量及 ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１ａ比值升高幅度均较Ｂ组明显低（Ｐ＜０．０１）。表明阿魏酸钠可明显抑制犬心脏停跳复苏后脑组织花生四烯酸代谢及脂质过氧化反应。
The content of TXB2, 6-keto-prostaglandin F1a (6-keto-PGF1a) and malondialdehyde (MDA) in brain tissue of 4-hour resuscitation of canine heart after cardioversion were investigated. influences. Seventeen dogs were randomly divided into non-ischemic control group (A group), conventional ischemia-reperfusion group (B group) and ischemia-reperfusion sodium ferulate group (C group). The results showed that TXB2, MDA content and TXB2 / 6-keto-PGF1a ratio in group B were significantly higher than those in group A (P <0.01). The levels of TXB2, MDA and the ratio of TXB2 / 6-keto-PGF1a in group C were significantly lower than those in group B (P <0.01). The results showed that sodium ferulate can significantly inhibit arachidonic acid metabolism and lipid peroxidation in brain tissue of dogs after cardiac arrest and resuscitation.